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Research Models and What a Convincing Trial Would Require Understanding why the answer to the title remains indicative, not proven is easier once you see how the compound has been studied and what a definitive study would demand

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*Correspondence: Weina Li, [email protected] Meng Li, [email protected] These authors have contributed equally to this work This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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