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If the cost of registration in a given year is lower, the lead registrant reimburses part of the cost corresponding to the other registrants

Altogether, these data suggest that e-cigarette aerosols may negatively alter morphology and impair immune responses in the upper airway epithelium depending on smoking history (Figure 7)

The most common adverse event associated with CHANTIX treatment is nausea, occurring in 30% of patients treated at the recommended dose, compared with 10% in patients taking a comparable placebo regimen [see Warnings and Precautions (5.9)]