when was tobacco introduced to jamestown and Staple Agriculture Cultivating Tobacco, Jamestown, 1615 |

An important factor that helps explain the difference in effects from these two substances is the amount of each that is typically smoked, Pletcher said

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The leaves were twisted by hand or spun on a small spinning machine into a thick rope, from which a ball containing from one to thirty pounds was made, though some were known to weigh as much as 105 pounds

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