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If people with mental illness have not been able to quit with first line treatment, consideration of NVPs in combination with behavioural support may be of value, although evidence specific to this group is currently lacking

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"It's not a substitute for things we know are effective -- increasing cigarette prices by raising taxes, funding evidence-based tobacco cessation programs, and passing smoke-free laws." Nonsmoking advocates like McGoldrick call the combination of those efforts the winning trifecta

A US variant of ZYN contains 15 pouches, while international variants contain 20 pouches