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"It's reflecting the increased interest of US smokers with new categories," he said, adding, "This is happening elsewhere and not just in the US." After the announcement, shares in US-listed tobacco rivals fell, with Altria down more than 3%, while Philip Morris shares slid more than 2%

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In vitro studies did not find inhibitory activity on CYP450 enzymes, but human studies are lacking ( A critical, but often overlooked, issue is the interaction between antidiabetic medications and smoking cessation

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