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Discussions with some of the respondents revealed that, among those who admitted to smoking occasionally but not being smokers, there were common criteria that many observed that technically kept them out of the smokers category

1747 was well before the requirement of informed consent of the patient, detailed eligibility criteria, protocols and regulations, which are a foundation of todays clinical research

Unlike caffeine, which mainly provides a temporary boost in alertness, or amphetamines, which can significantly enhance focus and energy levels, nicotines effects are more nuanced and multifaceted