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During the follow-up period, the serum creatinine levels and the urine dipstick test results of the subjects were measured two times (IQR: 34)

35 5.7.2 Smoking behaviour of siblings While research in this area can be difficult as it is challenging to successfully control for the range of shared characteristics affecting siblings, such as common family backgrounds, neighbourhoods, schools, and genes, which could potentially account for most of the observed correlations, 36 many studies have nonetheless found that living in a family with older brothers or sisters who smoke influences adolescent uptake of smoking, 1,24,25,37,38 with some research suggesting that it may be a more important predictor of uptake of smoking than parental smoking status

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