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First, most of the included studies relied on participants self-reported information regarding tobacco exposure and clinical outcomes that might be subject to misclassification and inaccurate reporting of both exposure and outcomes

In breast cancer, recurrence following primary breast cancer can be local (in the same place), regional (in surrounding tissue) or metastatic (in some other part of the body)., increases breast cancer mortality and is linked to poor prognosisThe expected or likely outcome of a disease, usually based on a statistical analysis of large groups of patients

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