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"Dopamine regulation of motivation for instance, is likely involved in the tendency of drug users to be overly preoccupied with drug use" to the exclusion of other forces in their lives like work and relationships, McClernon added.

This finding may be due to respondents who were dual/polytobacco users knowing that their parents disapprove of their behavior and regular supervision makes them feel more anxious and afraid that their parents/guardians will understand their behavior causes anxiety and contributes to the depression symptoms experienced