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Results: We found that cigarette smoke exposure inhibited cholesterol efflux by decreasing the expression of ABCA1, thereby increasing cholesterol accumulation in airway epithelial cells, which promotes the production of reactive oxygen species and promotes the secretion of inflammatory cytokines, ultimately aggravating cigarette smoke-induced airway inflammation
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Our team has also established a long-term collaboration with the local tobacco coalition, Tobacco Education & Advocacy of Midland, to gather valuable inputs and effectively disseminate research findings to the community
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