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p = 0.216) even after removing the rs1229984 variant, which had the strongest association with drinks per week and corresponded to the alcohol dehydrogenase 1B locus , in which the reduction in precision that is shown by wider confidence intervals and a non-significant p-value is expected as the variant rs1229984 has the strongest association with the drinks per week phenotype, but the value of the causal estimate (0.84) remained in the same direction and is in fact very close to the original estimate (0.79) and therefore we can conclude that the effect that alcohol drinking has over PD risk is not solely driven by the variant rs1229984 and thus horizontal pleiotropy is not underlying the association