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Glutathione biosynthesis occurs in two sequential, ATP-dependent enzymatic steps that take place in the cytosol: Step 1: The enzyme glutamate-cysteine ligase (GCL) combines glutamate and cysteine to form gamma-glutamylcysteine

The primary mechanism of action investigated in ex vivo and in vivo models involves the modulation of the nitric oxide (NO) system and the promotion of angiogenesis

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& Hegedus, L