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Even after she regained consciousness, she had altered mental status, her heart rate dropped, and she developed vomiting, profuse sweating, muscle twitching, and inability to control her copious secretions

Test marketing was short-lived and RJ Reynolds never commercialized its Nicotine Reduction Program or Project LN. 5 Vector Group commercialized Quest reduced-nicotine cigarettes in 2002, spending over $25 million on advertising before abandoning the product in 2006

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Model validation The validity of the meta-analytic tool has been extensively evaluated by Zheng and colleagues using simulation experiments 28,29