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ROR is a direct p53 target gene containing the p53 response element in its promoter and is also an important regulator that exerts its role by increasing the apoptosis level in DNA damage conditions [12, 28]

The additional buffering solution, NaHCO 3 (2.6 g/L), and reducing agents such as l-cysteine HCl (0.5 g/L) and 0.025% Na 2 S.9H 2 O were added, and the bottles were incubated at 60 C and 150 rpm for 20 days

For acetaldehyde [median (1 st quartile 3 rd quartile)], when using low nicotine concentrations without adjusting power (6F) the CRI was 2.7 10 6 (6.3 10 7 9.0 10 6 )

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