who grew tobacco during the colonial period Cultivation in 17th Century Virginia Tobacco - Discover Stafford

At Visit 3, if participants agree to continue in the study and did not meet any of the early withdrawal criteria, they are randomized to either (1) smoke the same UNC research cigarettes (~11.6 mg) for 18 weeks or (2) switch to progressively RNC research cigarettes over 18 weeks (Table 2)

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footnote 19 Health Canada will use this method to determine compliance with the maximum nicotine concentration

The answer depends on which "first" you're talking about, as multiple people shaped the devices we use