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To determine the nicotine exposure level in these animals, we measured the plasma concentration of cotinine, a major metabolite of nicotine

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The cigarette is held between the first and second knuckles of the index and middle fingers

Nicotine Addiction: Vapes vs Cigarettes Both products can cause strong nicotine dependence , but with different patterns: Cigarettes Provide fixed doses of nicotine Dependence is often tied to ritual behavior Vapes May allow higher or more frequent nicotine intake due to convenience Flavors increase appeal Youth are especially susceptible Nicotine affects brain development in young people, making both products concerning for minors