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"It actually makes the whole experience better than just burning the whole top -- this way, you dont have a bunch of green underneath a layer of ashes, and every hit has a little fresh bud in it." And Elvis adds, Its just rude

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Hence, one might postulate that given the potentially large effect size of the aforementioned factors associated with both smoking status and IBD, that the magnitude of any direct mechanistic or toxic effect of smoking constituents on the intestinal milieu or treatment(s) might in fact be dwarfed by these cofactors, as represented in Fig