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Ethics statement The animal study was reviewed and approved by Ethical Committee for Animal Experimentation of Nanfang Hospital

Material: Cigarette boxes are made from cardboard, paperboard, and plastic, which are biodegradable, recyclable, and environmentally friendly

Effects of COVD-19 Pandemic on Social Isolation and Loneliness A recent 2021 AARP survey on COVID-19 and emotional wellbeing reveals how the pandemic has taken its toll on older adults mental health

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