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En 2022, des chercheurs en chimie et toxicologues, au nom de la Society for research on nicotine and tobacco (SRNT), ont alert sur le fait que l'adjonction de ces additifs agents de fraicheur facilite l'initiation au tabagisme et aux produits du tabac [...] les connaissances sur le contenu des rafraichissants synthtiques dans les produits de cigarette lectronique commercialiss aux tats-Unis et les risques pour la sant associs sont encore limits [...] Des agents de refroidissement synthtiques (WS-3/WS-23) taient prsents dans les cigarettes lectroniques commercialises aux tats-Unis, des niveaux pouvant entraner une exposition des consommateurs dpassant les seuils de scurit fixs par les organismes de rglementation

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