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Globally, ~15% of couples of reproductive age are affected by infertility and the distribution of infertility due to male factor ranges from 20 to 70% with the prevalence of male infertility in North America, Australia, and Central and Eastern Europe varied from 4.5 to 6%, 9%, and 8 to 12%, respectively (Agarwal et al

Collectively, our findings emphasize brain regions (e.g., vmPFC, insula, thalamus) and circuits (e.g., insula-thalamus) linked with chronic smoking, suggest neuroimaging paradigms warranting additional consideration among smokers (e.g., pain processing), and point to regions in need of further elucidation in addiction (e.g., cerebellum)