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Blue or purple lips and fingernails

[174] Depression Like other physically addictive drugs, nicotine addiction causes a down-regulation of the production of dopamine and other stimulatory neurotransmitters as the brain attempts to compensate for the artificial stimulation caused by smoking

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The real public health emergency here is that smokers are being misled about the risk of switching to smoke-free products like e-cigarettes." The federal government announced this month that it will subject electronic cigarettes to regulations requiring manufacturers to submit their products for review