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Large-scale genome-wide association studies (GWAS) reported SNPs reliably associated with smoking and drinking behaviors 20,21

Results The global and regional burden of LCAS in 2021 Globally, the LCAS burden in 2021 amounted to 2,061,113 DALYs (95% UI: 1,838,5882,281,339) and 72,740 deaths (95% UI: 64,99280,488), with a corresponding age-standardized death rate (ASDR) of 23.38 per 10,000 population (95% UI: 20.8425.89) and an age-standardized mortality ratio (ASMR) of 0.89 per 10,000 population (95% UI: 0.800.99) (Table 1)

[Smoking also] causes lung diseases such as chronic bronchitis and emphysema, [and can] increase the risk of heart disease, including stroke, heart attack, vascular disease, and aneurysm." [7] According to the Surgeon General's Report of 2004, titled "The Health Consequences of Smoking", other consequences of smoking include increased risk of cataracts, lowered levels of antioxidants, especially vitamin C, heightened inflammation, and periodontitis