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Cellular Ca 2+ -load and RyR2 open-probability are increased, enhancing the risk of arrhythmogenic spontaneous Ca 2+ releases and afterdepolarizations (84)

The article provides a tool for governments and activists to prevent Big Tobacco from undermining, delaying, and watering down tobacco control policies at every turn

In a 2025 cross-sectional study of medical students in Saudi Arabia, 62.9 percent of nicotine pouch users reported quitting smoking entirely, and "more than half noted health improvements." A 2024 study of a randomized controlled trial published in Nicotine & Tobacco Research found that low-income adults who smoked daily and were not planning to quit significantly reduced their cigarette consumption after being given nicotine pouches

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