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In experimental models, researchers may explore processes such as hypothalamicpituitary axis signaling dynamics, insulin-like growth factor-1 (IGF-1)associated pathways, and downstream metabolic signaling mechanisms

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It makes sense then that if you have low B12 to the point of a deficiency, it can cause a myriad of physical and mental symptoms that can zap your energy and make you feel like you have one foot in the grave