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The opium, in strong doses, is a brain spinal depressor and it produces a comatose sleep with muscular relaxation, in small doses it stimulates the intellectual, nervous and muscular activity, and it acts as a great excitant to keep person awaken (Duprat, 1982) Talking about the arsenic, in its classical treaty of therapeutics, Manquat says: The action of the arsenic in the real gloves can be destructive, however, on the teeth is seems to act differently

(Li et al., 2018) demonstrated for the first time that ferroptosis occurred in the collagenase-induced ICH mouse model, and ferroptosis was observed in neurons within the 1mm range of the edge from hematoma by transmission electron microscopy