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873 The expression of ACSL4 and 4-HNE increase in the cartilage of OA patients and OA mice, while metformin increases p-AMPK and p-ACC levels in IL-1-treated chondrocytes, reverses ACSL4 and 4-HNE positive chondrocytes and OA lesions, and improves the ferroptosis sensitivity of chondrocytes through the AMPK/ACC pathway

Wu CC, Zhang J, Fujimoto J, Song X, Mao X, Sun H, Seth S, Thornton RL, Coyle MD, Little LD, Gumbs C, Behrens C, Chow CWB, Sulman EP, Rao G, Futreal A, Swisher SG , Wistuba II, Heymach JV, Gomez D, Zhang J

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With a complex molecule like glutathione, high bioavailability is the difference between a wasted effort and a successful wellness routine