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In the microenvironment of acute gout, where UA and H 2 O 2 levels are elevated, the nano-Pt in PDA@Pt not only catalyzes the degradation of UA through its uricase activity but also decomposes H 2 O 2 through its CAT activity, producing oxygen (O 2 ) and alleviating cellular hypoxia

Like avian intestinal calbindin-D 28K , mammalian intestinal calbindin-D 9K binds the absorbed calcium at the apical membrane and transports it across the cell to the basolateral membrane where it can be transported into the blood

912 Extensive research indicates that iron accumulation and decreased endogenous antioxidant defenses contribute significantly to the progression of sarcopenia

Angiogenic signaling and macrophage recruitment have been proposed as contributing mechanisms