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In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

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A possible explanation for the effects of N-terminally fused GRX on the E of roGFP probes might be a mechanical strain that acts on the GFP barrel slightly affecting the thermodynamic stability of the disulfide