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Selective estrogen receptor modulators (SERMs), which are also used in the treatment of uterine fibroids, can cause some side effects, such as vasomotor symptoms and thromboembolic events 18

( In neuronal cells, SIN markedly enhances the production of antioxidant enzymes like HO-1 and SOD, affecting both protein and mRNA levels, thereby triggering the Nrf2 pathway ( 5.4 Pharmacological effects of SIN in other diseases SIN has exhibited therapeutic efficacy in various diseases, including colitis ( and IL-6 and upregulating anti-inflammatory factors, SIN has anti-inflammatory actions that greatly improve experimental colitis ( In a CCI rat model, SIN exerts dose-dependent analgesic effects, significantly alleviating heat hyperalgesia and mechanical allodynia by increasing withdrawal reflex latency and elevating pain thresholds ( , IL-1, IL-6) and downregulation of RIP3, phosphorylated JNK, and c-Fos in the spinal cord, as well as an increased number of surviving neurons in the dorsal horn, indicating attenuation of CCI-induced neuronal death ( Beyond its role in inflammation and cancer, SIN also shows potential therapeutic efficacy in diseases such as diabetes, endotoxemia, asthma, cough, and depression

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