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These temperature fluctuations, while minor, are detrimental to the long-term stability of sensitive peptides

The deviation from linearity is probably due to geometric constraints in the roGFP barrel similar to those described for roGFP1-iR which had been expected to be less reducing than roGFP1-iL due to stabilization of the thiolate anion by the introduced adjacent basic arginine residue (Lohman and Remington, 2008)

In some cases, the target concentration will also depend on the specific therapeutic objectiveeg, the control of atrial fibrillation by digoxin often requires a target concentration of 2 ng/mL, while heart failure is usually adequately managed with a target concentration of 1 ng/mL

di Giovine, F