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This inflammation spreads to the brain, as peripheral cytokines cross the BBB, disrupting neuronal function and facilitating neuroinflammation (Rodrigues et al., 2023)

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N Engl J Med 364(6):514523 Pavel ME et al (2017) Health-related quality of life for everolimus versus placebo in patients with advanced, non-functional, well-differentiated gastrointestinal or lung neuroendocrine tumours (RADIANT-4): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

still, their effectiveness is limited, and no therapeutic strategy is able to fully stop OA progression