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Additionally, H&E and Safranin-O/Fast green staining showed that metformin treatment did not significantly ameliorate cartilage degradation induced by MIA-induced OA in Nrf2 KO mice (Fig

The dimer interface is formed by the interaction between loop 2 of one monomer and loop 1 of the other, stabilized by hydrogen bonds and salt bridges, resulting in a more open and flexible active site pocket compared to other GCTs

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