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Multiple other molecules with different routes of administration (such as oral GLP-1 RAs) and/or different mechanisms of action (such as injectable combinations of entero-pancreatic hormones) have shown promising data in early phase clinical trials and are currently undergoing phase 3 trials as treatments for T2D, obesity and other metabolic complications (e.c MASH, HFpEF) with some of them having the potential to induce even more WL and/or metabolic benefits compared to tirzepatide

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Researchers frequently employ *in vitro* models, such as primary cell cultures or established cell lines, where oxidative insults are induced using agents like hydrogen peroxide, menadione, or paraquat