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When catalpol was administered at 100 mg and 400 mg, the excretion rate in urine was 1.17 1.00 and 1.04 0.89 respectively, and the urine excretion was 1.17 1.00 and 4.17 3.55 respectively

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It is estimated that an adult human (mean weight, 70 kg) with moderate coffee intake consumes approximately 400 mg of caffeine per day, which is equivalent to 6 mg/kg per day or three cups of coffee