In fact, aging as well as degenerative and neuropsychiatric diseases, such as Parkinsons disease, Alzheimers disease, autism and schizophrenia, are associated with increased ROS production, the disruption of cellular GSH pools, and downregulation of GSH-dependent enzymes ( Because GSH does not readily penetrate the blood-brain barrier (BBB) ( de novo synthesis by two enzymes: -glutamate-cysteine ligase (GCL) and glutathione synthetase (GS) (Valdovinos-Flores and Gonsebatt, 2012)
10.1124/jpet.115.228932 15 Chavez-DozalA
Clusters with high centrality and density were identified as motor themes driving research progress, while clusters in other quadrants indicated emerging or specialized topics
The analysis was carried out in two parts: first, for the full 4 s trajectory of each system accounting for frames every 100 ns, and second, for the last 1 s of converged trajectory accounting for frames every 1 ns