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Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care

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The RIG-I protein is composed of three key parts: two caspase activation and recruitment domain (CARD) at the N-terminus, a repressor domain and the C-terminal domain (CTD) at the C-terminus, and a DexD/H helicase domain in the middle (54)