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In addition, since L-theanine was shown to have a relaxing effect and gamma-aminobutyric acid (GABA) was an important inhibitory neurotransmitter, the mixture of L-theanine and GABA had a positive synergistic effect on sleep behavior, including sleep quality and duration in caffeine-induced awake rats, and the mechanism might be that the mixture could promote the expression of GABA receptor, which was conducive to sleep (38)

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[DOI] [PubMed] [Google Scholar] 122.Miles M.P., Andring J.M., Pearson S.D., Gordon L.K., Kasper C., Depner C.M., Kidd J.R