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However, after irradiation, GPx1-KO and wild-type mice exhibited almost similar levels of intestinal GPx activity, and this was due to the radiation-induced compensatory upregulation of GPx2 in GPx1-KO mice

Another organo-selenium compound known for GPx-like activity, which has also been examined for radio-modulatory activity, is 3,3-diselenodipropionic acid (DSePA)

Future studies of oral GSH administration should consider reduced GSH status as an inclusion criteria, demonstrate increased levels of oxidative stress in study candidates prior to inclusion, and/or be performed in populations with increased oxidative burden (e.g., type 2 diabetes)