Such complexity highlights potential nodes for therapeutic intervention
A number of phenotypic elements should be carefully assessed, including neurological and cognitive symptoms (such as impairment of concentration and short-term memory, perceptual and sensory disturbances, sensory and emotional overload phenomena), autonomic manifestations (such as orthostatic intolerance, palpitations, gastro-intestinal symptoms), neuroendocrine manifestations (such as loss of thermostatic stability, intolerances of extremes of heat and cold, worsening symptoms with stress), and immune manifestations (such as tender lymph nodes, recurrent sore throat or flu-like symptoms, general malaise (flu-like feelings of being ill and feverish)
international journal of clinical chemistry, 333(1), 1939
In this regard, kojic acid-loaded SLNs showed higher drug concentration within the skin layers, controlled drug release, and greater tyrosinase inhibition capability was seen in comparison to the conventional formulation (Khezri et al., 2020b)
